Publications

Study design: Multicentric retrospective. Objective: The study of center of mass (COM) locations (i.e. barycentremetry) can help us understand postural alignment. This study goal was to determine relationships between COM locations and global postural alignment X-ray parameters in healthy subjects. The second objective was to determine the impact on spinopelvic alignment of increased distance between anterior body envelope and spine at lumbar apex level. Summary of background data: Unexplored relationship between COM location and spinopelvic parameters. Methods: This study included healthy volunteers with full-body biplanar radiograph including body envelope reconstruction, allowing the estimation of COM location. The following parameters were analyzed: lumbar lordosis (LL), thoracic kyphosis (TK), cervical lordosis (CL), pelvic tilt (PT), Sacro-femoral angle (SFA), Knee flexion angle (KFA), sagittal odontoid-hip axis angle (ODHA). The following COM in the sagittal plane were located: whole body, at thoracolumbar inflexion point, and body segment above TK apex. The body envelope reconstruction also provided the distance between anterior skin and the LL apex vertebral body center (“SV-L distance”). Results: This study included 124 volunteers, with a mean age of 44±19.3. Multivariate analysis confirmed posterior translation of COM above TK apex with increasing LL (P=0.002) through its proximal component, and posterior shift of COM at inflexion point with increasing TK (P=0.008). Increased SV-L distance was associated with greater ODHA (r=0.4) and more anterior body COM (r=0.8), caused by increased TK (r=0.2) and decreased proximal and distal LL (both r=0.3), resulting in an augmentation in SFA (r=0.3) (all P<0.01). Conclusions: Barycentremetry showed that greater LL was associated with posterior shift of COM above thoracic apex while greater TK was correlated with more posterior COM at inflexion point. Whole-body COM was strongly correlated with ODHA. This study also exhibited significant alignment disruption associated with increased abdominal volume, with compensatory hip extension. Level of evidence: II

Patients with obstructive sleep apneas (OSA) do not complain from dyspnea during resting breathing. Placement of a mandibular advancement device (MAD) can lead to a sense of improved respiratory comfort (“pseudo‐relief”) ascribed to a habituation phenomenon. To substantiate this conjecture, we hypothesized that, in non‐dyspneic awake OSA patients, respiratory‐related electroencephalographic figures, abnormally present during awake resting breathing, would disappear or change in parallel with MAD‐associated pseudo‐relief. In 20 patients, we compared natural breathing and breathing with MAD on: breathing discomfort (transitional visual analog scale, VAS‐2); upper airway mechanics, assessed in terms of pressure peak/time to peak (TTP) ratio respiratory‐related electroencephalography (EEG) signatures, including slow event‐related preinspiratory potentials; and a between‐state discrimination based on continuous connectivity evaluation. MAD improved breathing and upper airway mechanics. The 8 patients in whom the EEG between‐state discrimination was considered effective exhibited higher Peak/TTP improvement and transitional VAS ratings while wearing MAD than the 12 patients where it was not. These results support the notion of habituation to abnormal respiratory‐related afferents in OSA patients and fuel the causative nature of the relationship between dyspnea, respiratory‐related motor cortical activity and impaired upper airway mechanics in this setting.

Purpose Barycentremetry in adolescent idiopathic scoliosis (AIS) allows the distribution of masses and their loading of the spine to be studied. In particular, the axial torque on the spine has been studied in AIS, but not after surgical correction. Spinal axial torque was studied in AIS before and after surgery. Methods All AIS (Lenke 1 and 3) who underwent posterior spinal fusion surgery at our center in 2019 were included retrospectively. AIS underwent frontal and sagittal biplanar radiographs in the free-standing position before surgery, 4 months after surgery, and at the last follow-up. Their spine and external envelope were reconstructed with validated methods. Spinal axial torque at the apex and the upper and lower end vertebra was calculated. Finally, the preoperative and postoperative values were compared to a previously published reference corridor for asymptomatic subjects. Results Twenty-nine patients were included (54 ± 11° Cobb angle, 15 ± 2 years old at surgery). The surgical procedure decreased the Cobb angle by 36° ± 11° and decreased the spinal axial torque at the upper end vertebra by 2.5 N/m (95% CI = [1.9; 3]; p < 0.001), at the apex by 0.6 N/m (95% CI = [0.4; 1]; p = 0.004), at the lower end vertebra by 2 N/m (95% CI = [1.5; 2.8]; p < 0.001). Compared to 95th percentile of torque, which was previously evaluated in asymptomatic subjects, more than 90% of patients had higher values at the upper and lower end vertebrae before surgery. Postoperatively, 62% of patients still had higher torque at the upper end vertebra than asymptomatic subjects, while only 38% patients showed abnormal values at the lower junction. Conclusion Results of this study confirm that AIS patients show abnormally high spinal axial torque, especially at the end vertebrae, and that this parameter is normalized postoperatively for only a small number of patients.

This article aims at proposing a new mean-field homogenization framework for the study of composites undergoing fully coupled thermomechanical processes. Strongly dissipative phenomena during high or moderate cyclic loading conditions in a structural component made of a composite material cause significant interplay between mechanical and thermal fields. The proposed framework attempts to address such effect by combining the Mori-Tanaka scheme and the Transformation Field Analysis (TFA) theory and by developing a multiscale framework capable of taking into account thermomechanically coupled processes. The numerical simulations performed in the examples section and validations with computations using periodic homogenization and full-structure analysis demonstrate the proposed strategy’s accuracy and robustness. The numerical simulation of a tube shows the model’s ability to simulate cyclic loading conditions with significantly less computational cost than the alternative FE 2 computation strategies. This drastic computational time reduction is due to the semi-analytical formalism of the micromechanics methodology.

Design is a dynamic, decision-driven process, often guided by intuition and experience. It can be susceptible to cognitive biases, systematic deviations in information processing and decision making, which have been recognized as influential factors affecting expert judgment in multiple domains. Although some studies in the design field have investigated and proposed methods to address specific biases, such as the confirmation bias, there is currently no comprehensive approach in the literature to make designers aware of the various biases that may manifest during the design process. The main contribution of this article is to provide designers with a broad overview of the biases that may be involved within the three principal areas of design cognition: problem formulation, concept generation and concept evaluation. It also proposes a novel and workable methodology to facilitate designers' recognition and mitigation of biases through metacognition, while favoring the implementation of more specific correction strategies.

Supercritical water oxidation (SCWO) with hydrothermal flames is well established for the treatment of aqueous organic waste as it not only overcomes the limitations of simple SCWO, such as precipitation of salts, but also exhibits many advantages over other waste treatment processes. Seeking these advantages, we propose to perform SCWO using hydrothermal flames in microfluidic reactors ) for aerospace applications to be used in deep space/ISS missions. The novelty and highlight of this work are successful demonstration of realizing microreactors (channel width 200 ), which can withstand pressure of 250 bar with temperature °C, thereby presenting the feasibility to realize this technology. We present the first evidence of SCWO/hydrothermal in a flow microreactor of sapphire, which is captured through optical visualization. This is followed by a numerical investigation to understand the underlying physics leading to the formation of hydrothermal flame and thus differentiate it from a simple SCWO reaction. The simulations are performed in a 2D domain in a co-flow configuration with equal inlet velocity of fuel and oxidizer at two different inlet temperatures (350 °C and 365 °C), just below the critical temperature of water using ethanol and oxygen, the former acting not only as a model organic matter but also fuel for the formation of hydrothermal flames. It is observed that due to microscale size of the system, hydrothermal flames are formed at low inlet velocities (< 30 mm/s), while reaction at higher ones are characterized as simple SCWO reaction. This upper limit of inlet velocity was found to increase with inlet temperature. Finally, some key characteristics of hydrothermal flames - ignition delay time, flame structure, shape, and local propagation speed are analyzed.

Most of biopharmaceuticals, in their liquid form, are prone to instabilities during storage. In order to improve their stability, lyophilization is the most commonly used drying technique in the pharmaceutical industry. In addition, certain applications of biopharmaceutical products can be considered by oral administration and tablets are the most frequent solid pharmaceutical dosage form used for oral route. Thus, the tableting properties of freeze-dried products used as cryo and lyoprotectant could be a key element for future pharmaceutical developments and applications. In this study, we investigated the properties that might play a particular role in the specific compaction behavior of freeze-dried excipients. The tableting properties of freeze-dried trehalose, lactose and mannitol were investigated and compared to other forms of these excipients (spray-dried, commercial crystalline and commercial crystalline milled powders). The obtained results showed a specific behavior in terms of compressibility, tabletability and brittleness for the amorphous powders obtained after freeze-drying. The comparison with the other powders showed that this specific tableting behavior is linked to both the specific texture and the physical state (amorphization) of these freeze-dried powders.

A new model predicting the whole-body Dynamic Mean thermal sensation Vote (DMV) is described. The model is useful for evaluating transient thermal conditions but is limited to uniform ones. It is based on physiological signals (mean skin temperature and its rate of change, mean skin wittedness, and core body temperature) simulated by using Gagge's two-node thermophysiological model. It is derived from empirical data obtained through experiments conducted under 160 steady-state thermal exposures at rest, 60 transient thermal conditions at rest, and 24 static thermal conditions during exercise. An independent validation is performed against 13 transient thermal conditions during exercise. The model shows good agreement (RMSE less than 0.5) with experimental observations within the range of air temperatures between 15 and 37 °C and when activity levels are below 3 met. It performs better than the widely used Fanger's PMV model, especially when far from thermal neutrality, for step-change thermal transients, and under exercise conditions. Furthermore, the model's simplicity and low computational cost are important advantages over more complex and computationally expensive thermal sensation models based on multi-segment and multi-node thermophysiological models.

After the Notre-Dame de Paris (NDP) Cathedral fire, a structural analysis was undertaken to provide decision support for architects in charge of diagnosis and repair operations. Due to the potential impact of the results on the renovation project, calculations on the vaults and walls of the monument were compared to increase their reliability. This article presents the 3 modelling strategies implemented: 2 discrete block-to-block 3D approaches (DEM and FEM) and 1 continuum 3D approach (FEM). The assumptions common to the 3 approaches are presented. They mainly concern the geometrical model, the thermal actions and a diagnosis methodology called the working point method, previously used by the authors on other Gothic vaults. Comparisons of the results with each other and with on-site deflection measurements should lead to validation of the calculation strategies. The analysis will highlight the strengths and weaknesses of the computational approaches and propose research perspectives. Future developments concern the determination of models of homogenized thermomechanical behaviour of masonry and the development of a new hybrid calculation tool taking advantage of the continuum and discontinuum approaches detailed in this article.

Machine learning has seen increasing implementation as a predictive tool in the chemical and physical sciences in recent years. It offers a route to accelerate the process of scientific discovery through a computational data-driven approach. Whilst machine learning is well established in other fields, such as pharmaceutical research, it is still in its infancy in supercritical fluids research, but will likely accelerate dramatically in coming years. In this review, we present a basic introduction to machine learning and discuss its current uses by supercritical fluids researchers. In particular, we focus on the most common machine learning applications; including: (1) The estimation of the thermodynamic properties of supercritical fluids. (2) The estimation of solubilities, miscibilities, and extraction yields. (3) Chemical reaction optimization. (4) Materials synthesis optimization. (5) Supercritical power systems. (6) Fluid dynamics simulations of supercritical fluids. (7) Molecular simulation of supercritical fluids and (8) Geosequestration of CO2 using supercritical fluids.